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The chemical reactions and pathways involving monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-). The chemical reactions and pathways involving 4-hydroxyproline, C5H9NO3, a derivative of the amino acid proline. The presence of hydroxyproline is essential to produce stable triple helical tropocollagen, hence the problems caused by ascorbate deficiency in scurvy. This unusual amino acid is also present in considerable amounts in the major glycoprotein of primary plant cell walls. The modification of peptidyl-proline. The posttranslational modification of peptidyl-proline to form 4-hydroxy-L-proline; catalyzed by procollagen-proline,2-oxoglutarate-4-dioxygenase. The chemical reactions and pathways involving compounds derived from amino acids, organic acids containing one or more amino substituents. The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group, as carried out by individual cells. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom. The hydroxylation of peptidyl-proline to form peptidyl-hydroxyproline. The chemical reactions and pathways involving heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings).

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: peptidyl-proline hydroxylation to 4-hydroxy-L-proline
Acc: GO:0018401
Aspect: Biological Process
Desc: The posttranslational modification of peptidyl-proline to form 4-hydroxy-L-proline; catalyzed by procollagen-proline,2-oxoglutarate-4-dioxygenase.
Proteins in PDR annotated with:
   This term: 40 [Search]
   Term or descendants: 40 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0018401 - peptidyl-proline hydroxylation to 4-hydroxy-L-proline (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle