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The modification of peptidyl-asparagine. The chemical reactions and pathways resulting in the formation of phosphoinositides, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of inositol. The alteration of an amino acid residue in a peptide. The covalent or non-covalent attachment of lipid moieties to an amino acid in a protein. The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol moiety is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate moiety, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage. The chemical reactions and pathways resulting in the formation of a C-terminal peptidyl-asparagine ethanolamide-linked glycosylphosphatidylinositol (GPI) anchor following hydrolysis of a asparaginyl-peptide bond in the carboxy-terminal region of a membrane-associated protein. The chemical reactions and pathways involving glycosylphosphatidylinositol anchors, molecular mechanisms for attaching membrane proteins to the lipid bilayer of cell membranes. Structurally they consist of a molecule of phosphatidylinositol to which is linked, via the C-6 hydroxyl of the inositol, a carbohydrate chain. This chain is in turn linked to the protein through an ethanolamine phosphate moiety, the amino group of which is in amide linkage with the C-terminal carboxyl of the protein chain, the phosphate group being esterified to the C-6 hydroxyl of the terminal mannose of the core carbohydrate chain.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: GPI anchor biosynthetic process via N-asparaginyl-glycosylphosphatidylinositolethanolamine
Acc: GO:0018265
Aspect: Biological Process
Desc: The chemical reactions and pathways resulting in the formation of a C-terminal peptidyl-asparagine ethanolamide-linked glycosylphosphatidylinositol (GPI) anchor following hydrolysis of a asparaginyl-peptide bond in the carboxy-terminal region of a membrane-associated protein.
Synonyms:
  • GPI anchor formation via N-asparaginyl-glycosylphosphatidylinositolethanolamine
  • GPI anchor anabolism via N-asparaginyl-glycosylphosphatidylinositolethanolamine
  • GPI anchor synthesis via N-asparaginyl-glycosylphosphatidylinositolethanolamine
Proteins in PDR annotated with:
   This term: 0
   Term or descendants: 0


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0018265 - GPI anchor biosynthetic process via N-asparaginyl-glycosylphosphatidylinositolethanolamine (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle