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Catalysis of the transfer of sulfur atoms from one compound (donor) to another (acceptor). Catalysis of the transfer of a sulfur-containing group from one compound (donor) to another (acceptor). Catalysis of the formation of carbon-nitrogen bonds between lipoate (5-(1,2-dithiolan-3-yl)pentanoate) and a protein. Catalysis of a reaction in which S-adenosyl-L-methionine (SAM) undergoes reductive cleavage to serve as a source of the 5'-deoxyadenosyl radical. Catalysis of the reaction: protein N6-(octanoyl)lysine + 2 sulfur + 2 S-adenosyl-L-methionine = protein N6-(lipoyl)lysine + 2 L-methionine + 2 5'-deoxyadenosyl. Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. Catalysis of the ligation of two substances via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: lipoate synthase activity
Acc: GO:0016992
Aspect: Molecular Function
Desc: Catalysis of the reaction: protein N6-(octanoyl)lysine + 2 sulfur + 2 S-adenosyl-L-methionine = protein N6-(lipoyl)lysine + 2 L-methionine + 2 5'-deoxyadenosyl.
Synonyms:
  • protein 6-N-(octanoyl)lysine:sulfur sulfurtransferase activity
  • lipoyl synthase activity
  • LS
  • LipA
  • protein N6-(octanoyl)lysine:sulfur sulfurtransferase activity
Proteins in PDR annotated with:
   This term: 10 [Search]
   Term or descendants: 10 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0016992 - lipoate synthase activity (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle