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Catalysis of the reaction: cis-4-(8-hydroxypyren-7-yl)-2-oxobut-3-enoate = 10-Oxabenzo(def)chrysen-9-one + formate + H+. Catalysis of the cleavage of a C-C bond by other means than by hydrolysis or oxidation, of a 3-hydroxy acid. Catalysis of the reaction: (2Z)-2,4-dihydroxydec-2-enedioate = pyruvate + 7-oxoheptanoate. Catalysis of the reaction: isocitrate = succinate + glyoxylate. Catalysis of the reaction: (3S)-3-carboxy-3-hydroxypropanoyl-CoA = acetyl-CoA + glyoxylate. Catalysis of the reaction: 4-hydroxy-4-methyl-2-oxoglutarate = 2 pyruvate. Catalysis of the reaction: 5-chloro-4-hydroxy-2-oxopentanate = pyruvate + chloroacetaldehyde. Catalysis of the reaction: 4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate. Catalysis of the reaction: 4-hydroxy-2-oxopentanoate = pyruvate + acetaldehyde. Catalysis of the reaction: erythro-3-hydroxy-L-aspartate = glycine + glyoxylate. Catalysis of the reaction: chorismate = 4-hydroxybenzoate + pyruvate. Catalysis of the reaction: (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate. Catalysis of the reaction: propionyl-CoA + glyoxylate = L-erythro-3-methylmalyl-CoA. Catalysis of the reaction: (3S)-citryl-CoA = acetyl-CoA + oxaloacetate. Catalysis of the reaction: citrate = acetate + oxaloacetate. Catalysis of the reaction: chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate. Catalysis of the reaction: 3-oxalomalate = oxaloacetate + glyoxylate. Catalysis of the reaction: O-succinylbenzoyl-CoA = 1,4-dihydroxy-2-naphthoate + CoA. Catalysis of the reaction: 4-amino-4-deoxychorismate = p-aminobenzoate + pyruvate. Catalysis of the reaction: (R)-citramalyl-CoA = pyruvate + acetyl-CoA. Catalysis of the reaction: 2,3-dimethylmalate = propanoate + pyruvate. Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. Catalysis of the reaction: isochorismate = salicylate + pyruvate. Catalysis of the reaction: N-acetylneuraminate = N-acetyl-D-mannosamine + pyruvate. Catalysis of the reaction: (3S)-citramalyl-CoA = acetyl-CoA + pyruvate. Catalysis of the reaction: (3S)-citramalate = acetate + pyruvate. Catalysis of the reaction: (1-hydroxycyclohexan-1-yl)acetyl-CoA = cyclohexanone + acetyl-CoA. Catalysis of the reaction: 3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA = acetate + 7-methyl-3-oxooctanoyl-CoA. Catalysis of the cleavage of C-C bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. Catalysis of the reaction: (S)-3-hydroxy-3-methylglutaryl-CoA = acetyl-CoA + acetoacetate.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: oxo-acid-lyase activity
Acc: GO:0016833
Aspect: Molecular Function
Desc: Catalysis of the cleavage of a C-C bond by other means than by hydrolysis or oxidation, of a 3-hydroxy acid.
Synonyms:
  • oxoacid lyase activity
  • oxo-acid lyase activity
Proteins in PDR annotated with:
   This term: 13 [Search]
   Term or descendants: 128 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0016833 - oxo-acid-lyase activity (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle