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Catalysis of the reaction: N-acylneuraminate 9-phosphate + H2O = N-acylneuraminate + phosphate. Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum. Catalysis of the reaction: 5-amino-6-(5-phosphoribitylamino)-2,4(1H,3H)-pyrimidinedione + H2O = 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione + orthophosphate. Catalysis of the reaction: dolichyl phosphate + H2O = dolichol + phosphate. Catalysis of the reaction: carbohydrate phosphate + H2O = carbohydrate + phosphate. Catalysis of the reaction: D-mannitol 1-phosphate + H2O = D-mannitol + phosphate. Catalysis of the reaction: phosphopolynucleotide + H2O = polynucleotide + phosphate. Catalysis of the reaction: myo-inositol hexakisphosphate + H2O = D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate. Catalysis of the reaction: aryl dialkyl phosphate + H2O = dialkyl phosphate + an aryl alcohol. Catalysis of the reaction: caldesmon phosphate + H2O = caldesmon + phosphate. Catalysis of the reaction: (9S,10S)-10-hydroxy-9-(phosphonooxy)octadecanoate + H2O = (9S,10S)-9,10-dihydroxyoctadecanoate + phosphate. Catalysis of the reactions: O-phosphoethanolamine + H2O = ethanolamine + phosphate and phosphocholine + H2O = choline + phosphate. Catalysis of the reaction: pyridoxal 5'-phosphate + H2O = pyridoxal + phosphate. Catalysis of the reactions: 5-(methylthio)-2,3-dioxopentyl phosphate + H2O = 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + phosphate (1a) 5-(methylthio)-2,3-dioxopentyl phosphate = 2-hydroxy-5-(methylthio)-3-oxopent-1-enyl phosphate (1b) 2-hydroxy-5-(methylthio)-3-oxopent-1-enyl phosphate + H2O = 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + phosphate. Catalysis of the reaction: [pyruvate dehydrogenase (lipoamide)] phosphate + H2O = [pyruvate dehydrogenase (lipoamide)] + phosphate. Catalysis of the reaction: H2O + myo-inositol hexakisphosphate = phosphate + 1L-myo-inositol 1,2,3,4,6-pentakisphosphate. Catalysis of the reaction: 2(alpha-D-mannosyl)-3-phosphoglycerate + H2O = 2(alpha-D-mannosyl)-D-glycerate + phosphate. Catalysis of the reaction: 2-phospho-3-sulfolactate + H2O = 3-sulfolactate + phosphate. Catalysis of the reaction: glycerol 1-phosphate + H2O = glycerol + phosphate. Catalysis of the reaction: 1-alkyl-2-acetyl-sn-glycero-3-phosphate + H2O = 1-alkyl-2-acetyl-sn-glycerol + phosphate. Catalysis of the reaction: 2-(beta-D-glucosyl)-sn-glycerol-3-phosphate + H2O = 2-(beta-D-glucosyl)-sn-glycerol + phosphate. Catalysis of the reaction: myo-inositol hexakisphosphate + H2O = 1-myo-inositol 1,2,3,4,5-pentakisphosphate + phosphate. Catalysis of the reaction: myosin light-chain phosphate + H2O = myosin light chain + phosphate. Catalysis of the reaction: L(or D)-O-phosphoserine + H2O = L(or D)-serine + phosphate. Catalysis of the reaction: dihydrosphingosine 1-phosphate + H2O = dihydrosphingosine + phosphate. Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum. Catalysis of the reaction: glycerol 3-phosphate + H2O = glycerol + phosphate. Catalysis of the reaction: [acetyl-CoA carboxylase]-phosphate + H2O = [acetyl-CoA carboxylase] + phosphate. Catalysis of the reaction: H2O + NADP+ = NAD+ + phosphate. Catalysis of the reaction: 2-carboxy-D-arabinitol 1-phosphate + H2O = 2-carboxy-D-arabinitol + phosphate. Catalysis of the reaction: [glycogen-synthase D] + H2O = [glycogen-synthase I] + phosphate. Catalysis of the reaction: [pyruvate kinase] phosphate + H2O = [pyruvate kinase] + phosphate. Catalysis of the reaction: a deoxynucleoside 3'-phosphate + H2O = a deoxynucleoside + phosphate. Catalysis of the reaction: sorbitol 6-phosphate + H2O = sorbitol + phosphate. Catalysis of the reaction: 4-nitrophenyl phosphate + H2O = 4-nitrophenol + phosphate. Catalysis of the reaction: streptomycin 6-phosphate + H2O = streptomycin + phosphate. Catalysis of the hydrolysis of any ester bond. Catalysis of the reaction: thymidylate + H2O = thymidine + phosphate. Catalysis of the reaction: alpha-ribazole-5'-phosphate = alpha-ribazole + phosphate. Catalysis of the reaction: sucrose 6F-phosphate + H2O = sucrose + phosphate. Catalysis of the reaction: sugar phosphate + H2O = sugar + phosphate. Catalysis of the reaction: phosphoenolpyruvate + H2O = pyruvate + phosphate. Catalysis of the conversion of phosphatidylinositol-3-phosphate, phosphatidylinositol-4-phosphate, and phosphatidylinositol-3,5-bisphosphate, but not PI-4,5-bisphosphate, to phosphatidylinositol; PPIPase activity is a key regulator of membrane trafficking and actin cytoskeleton organization. Catalysis of the reaction: sphingosine 1-phosphate + H2O = sphingosine + phosphate. Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. Catalysis of the reaction: RPO-R' + H2O = RPOOH + R'H. This reaction is the hydrolysis of any phosphoric ester bond, any ester formed from orthophosphoric acid, O=P(OH)3. Catalysis of the reaction: a phospholipid + H2O = a lipid + phosphate. Catalysis of the reaction: D-beta-D-heptose 1,7-bisphosphate + H2O = D-beta-D-heptose 1-phosphate + phosphate. Catalysis of the reaction: D-glycerate 2-phosphate + H2O = D-glycerate + phosphate. Catalysis of the reaction: phosphatidylglycerophosphate + H2O = phosphatidylglycerol + phosphate. Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity. Catalysis of the reaction: [phosphorylase a] + 4 H2O = 2 [phosphorylase b] + 4 phosphate. Catalysis of the reaction: 2-phosphoglycolate + H2O = glycolate + phosphate. Cataysis of the dephosphorylation of 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-P) to 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Catalysis of the reaction: 2,3-diphosphoglycerate + H2O = phosphoglycerate + phosphate. Catalysis of the reaction: phosphohistidine + H2O = histidine + phosphate. Catalysis of the reaction: L-histidinol-phosphate + H2O = L-histidinol + phosphate. Catalysis of the reaction: galactose-1-phosphate + H2O = galactose + phosphate. Catalysis of the reaction: sedoheptulose 1,7-bisphosphate + H2O = sedoheptulose 7-phosphate + phosphate. Catalysis of the reaction: alpha-ribazole 5'-phosphate + H2O = alpha-ribazole + phosphate. Catalysis of the reaction: a 3-sn-phosphatidate + H2O = a 1,2-diacyl-sn-glycerol + phosphate. Catalysis of the reaction: D-glycerate 3-phosphate + H2O = D-glycerate + phosphate. Catalysis of the reaction: 3-(ADP)-2-phosphoglycerate + H2O = 3-(ADP)-glycerate + phosphate. Catalysis of the reaction: 3-deoxy-D-manno-octulosonate 8-phosphate + H2O = 3-deoxy-D-manno-octulosonate + phosphate. Catalysis of the removal of a phosphate group from phosphorylated myo-inositol (1,2,3,5/4,6-cyclohexanehexol) or a phosphatidylinositol. Catalysis of the reaction: H2O + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphate = phosphate + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)]. Catalysis of the reaction: H2O + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate = phosphate + [hydroxymethylglutaryl-CoA reductase (NADPH)]. Catalysis of the reaction: a nucleotide + H2O = a nucleoside + phosphate. Catalysis of the reaction: H2O + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate = phosphate + 1-guanidino-1-deoxy-scyllo-inositol. Catalysis of the reaction: H2O + S-methyl-3-phospho-1-thio-D-glycerate = phosphate + S-methyl-1-thio-D-glycerate. Catalysis of the reaction: glycerol 2-phosphate + H2O = glycerol + phosphate. Catalysis of the reaction: H2O + D-fructose 2,6-bisphosphate = phosphate + fructose-2-phosphate.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: phosphatase activity
Acc: GO:0016791
Aspect: Molecular Function
Desc: Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate.
Synonyms:
  • phosphoric monoester hydrolase activity
  • phosphatase
  • GO:0016302
Proteins in PDR annotated with:
   This term: 506 [Search]
   Term or descendants: 2031 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0016791 - phosphatase activity (interactive image map)
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