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Mutations occurring somatically that result in amino acid changes in the rearranged V regions of immunoglobulins following the induction of an immune response. The somatic process allowing for the production of immune receptors whose specificity is not encoded in the germline genomic sequences. The somatic process by means of which sequence diversity of immunoglobulins is generated. Mutations occurring somatically that result in amino acid changes in the rearranged V regions of immunoglobulins. The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. The process by which immune receptor genes are diversified through somatic mutation.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: somatic hypermutation of immunoglobulin genes
Acc: GO:0016446
Aspect: Biological Process
Desc: Mutations occurring somatically that result in amino acid changes in the rearranged V regions of immunoglobulins.
Synonyms:
  • somatic hypermutation of antibody genes
Proteins in PDR annotated with:
   This term: 11 [Search]
   Term or descendants: 11 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0016446 - somatic hypermutation of immunoglobulin genes (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle