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The somatic process by means of which sequence diversity of immunoglobulins is generated after the induction of an immune response. The generation of alternate transcripts of immunoglobulin genes through alternate splicing of exons. The somatic process by which immunoglobulin genes are diversified through the mechanism of gene conversion. The addition of variable numbers of random nucleotides by terminal deoxytransferase in the N regions of heavy chain immunoglobulin genes. N regions are found at the V-D and D-J recombinational junctions. The process by which immunoglobulin genes are formed through recombination of the germline genetic elements, as known as immunoglobulin gene segments, within a single locus. The synthesis or release of any molecular mediator of the immune response following an immunological stimulus, resulting in an increase in its intracellular or extracellular levels. The somatic process allowing for the production of immune receptors whose specificity is not encoded in the germline genomic sequences. The somatic process by means of which sequence diversity of immunoglobulins is generated. Mutations occurring somatically that result in amino acid changes in the rearranged V regions of immunoglobulins. The process whose specific outcome is the progression of an organismal system whose objective is to provide calibrated responses by an organism to a potential internal or invasive threat, over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process. The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: somatic diversification of immunoglobulins
Acc: GO:0016445
Aspect: Biological Process
Desc: The somatic process by means of which sequence diversity of immunoglobulins is generated.
Synonyms:
  • somatic diversification of antibodies
Proteins in PDR annotated with:
   This term: 2 [Search]
   Term or descendants: 59 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0016445 - somatic diversification of immunoglobulins (interactive image map)
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