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Catalysis of the endonucleolytic cleavage of DNA in a site specific manner. Cleavage is dependent on the presence of a specific recognition site in the DNA which must be modified (e.g. methylated, hydroxymethylated, glucosyl-hydroxymethylated). Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid. Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks. Catalysis of endonucleolytic cleavage of DNA in a site-specific manner, resulting in double-strand breaks. Catalysis of the endonucleolytic cleavage of DNA to give double-stranded fragments with terminal 5'-phosphates. ATP hydrolysis is required. Cleavage is dependent on the presence of two copies of a specific recognition sequence in an inverse orientation in the DNA. Cleavage occurs at a specific distance from one of the recognition sites. Catalysis of the endonucleolytic cleavage of DNA to give random double-stranded fragments with terminal 5' or 3' protrusions; ATP is simultaneously hydrolyzed. Cleavage is dependent on the presence in the DNA of a specific recognition site. Cleavage may occur hundreds or thousands of base pairs away from the recognition site due to translocation of DNA. Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks. Catalysis of the endonucleolytic cleavage of DNA to give specific double-stranded fragments with terminal 5'-phosphates and 3' hydroxyls. Cleavage is dependent on the presence in the DNA of a specific recognition site; cleavage occurs at or very near this recognition site.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: restriction endodeoxyribonuclease activity
Acc: GO:0015666
Aspect: Molecular Function
Desc: Catalysis of endonucleolytic cleavage of DNA in a site-specific manner, resulting in double-strand breaks.
Synonyms:
  • restriction enzyme activity
  • restriction endonuclease activity
Proteins in PDR annotated with:
   This term: 8 [Search]
   Term or descendants: 16 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0015666 - restriction endodeoxyribonuclease activity (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle