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Enables the transfer of a substance from one side of a membrane to the other. Enables the directed movement of methotrexate, 4-amino-10-methylformic acid, into, out of, within or between cells. Methotrexate is a folic acid analogue and a potent competitive inhibitor of dihydrofolate reductase. Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: methotrexate transporter activity
Acc: GO:0015350
Aspect: Molecular Function
Desc: Enables the directed movement of methotrexate, 4-amino-10-methylformic acid, into, out of, within or between cells. Methotrexate is a folic acid analogue and a potent competitive inhibitor of dihydrofolate reductase.
Proteins in PDR annotated with:
   This term: 8 [Search]
   Term or descendants: 8 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0015350 - methotrexate transporter activity (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle