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Catalysis of endonucleolytic cleavage of DNA in a site-specific manner, resulting in double-strand breaks. Catalysis of the endonucleolytic cleavage of DNA to give random double-stranded fragments with terminal 5' or 3' protrusions; ATP is simultaneously hydrolyzed. Cleavage is dependent on the presence in the DNA of a specific recognition site. Cleavage may occur hundreds or thousands of base pairs away from the recognition site due to translocation of DNA. Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks to yield 5'-phosphomonoesters. Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks. Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: Type I site-specific deoxyribonuclease activity
Acc: GO:0009035
Aspect: Molecular Function
Desc: Catalysis of the endonucleolytic cleavage of DNA to give random double-stranded fragments with terminal 5' or 3' protrusions; ATP is simultaneously hydrolyzed. Cleavage is dependent on the presence in the DNA of a specific recognition site. Cleavage may occur hundreds or thousands of base pairs away from the recognition site due to translocation of DNA.
Synonyms:
  • deoxyribonuclease (adenosine triphosphate-hydrolyzing)
  • adenosine triphosphate-dependent deoxyribonuclease activity
  • Type I restriction enzyme activity
  • ATP-dependent DNase activity
  • type I site-specific deoxyribonuclease activity
  • deoxyribonuclease (ATP- and S-adenosyl-L-methionine-dependent)
Proteins in PDR annotated with:
   This term: 5 [Search]
   Term or descendants: 5 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0009035 - Type I site-specific deoxyribonuclease activity (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle