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null Catalysis of the hydrolysis of any ester bond. Catalysis of the reaction: a phosphatidylcholine + H2O = choline + a phosphatidate. Catalysis of the reaction: H2O + cyclic di-3',5'-guanylate + H2O = 5'-phosphoguanylyl(3'->5')guanosine. Catalysis of the hydrolysis of phosphotyrosyl moieties formed as covalent intermediates (in DNA backbone breakage) between a DNA topoisomerase and DNA. Catalysis of the reaction: dolichyl beta-D-glucosyl phosphate + H2O = dolichol-phosphate + beta-D-glucose. Catalysis of the reaction: a phospholipid + H2O = 1,2-diacylglycerol + a phosphatidate. Catalysis of the reaction: dolichyl beta-D-mannosyl phosphate + H2O = dolichol-phosphate + mannose. Catalysis of the reaction: RPO-R' + H2O = RPOOH + R'H. This reaction is the hydrolysis of any phosphoric ester bond, any ester formed from orthophosphoric acid, O=P(OH)3. Catalysis of the reaction: H2O + 6-(D-glucose-1-phospho)-D-mannosylglycoprotein = D-mannosylglycoprotein + D-glucose-alpha-1-phosphate. Catalysis of the sequential hydrolytic removal of 5'-nucleotides from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides. Catalysis of the reaction: H2O + glycerol 1,2-cyclic phosphate = glycerol-3-phosphate. Catalysis of the reaction: H2O + 1-(sn-glycero-3-phospho)-1D-myoinositol = 1D-myo-inositol 1-phosphate + glycerol. Catalysis of the reaction: H2O + sn-glycero-3-phospho-1-inositol = glycerol-3-phosphate + inositol. Catalysis of the reaction: H2O + L-1-glycero-3-phosphocholine = phosphoryl-choline + glycerol. Catalysis of the reaction: H2O + 1-alkyl-sn-glycero-3-phosphoethanolamine = ethanol-amine + 1-alkyl-sn-glycerol 3-phosphate. Catalysis of the reaction: sphingomyelin + H2O = ceramide phosphate + choline. Catalysis of the reaction: H2O + CMP-N-acylneuraminate = N-acylneuraminate + CMP. Catalysis of the reaction: a glycerophosphodiester + H2O = an alcohol + sn-glycerol 3-phosphate. Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group. Catalysis of the reaction: sphingomyelin + H2O = N-acylsphingosine + choline phosphate. Catalysis of the reaction: a nucleoside cyclic phosphate + H2O = a nucleoside phosphate. Catalysis of the reaction: [acyl-carrier protein] + H2O = 4'-phosphopantetheine + apoprotein. Catalysis of the release of N-acylethanolamine from N-acyl-phosphatidylethanolamine (NAPE) to generate N-acylethanolamine (NAE). Catalysis of the reaction: H2O + L-1-glycero-3-phosphocholine = glycerol-3-phosphate + choline. Catalysis of the reaction: H2O + adenylyl-GS = glutaminesyn-oligomer + AMP. Catalysis of the reaction: H2O + serine phosphoethanolamine = phosphoryl-ethanolamine + L-serine.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: phosphoric diester hydrolase activity
Acc: GO:0008081
Aspect: Molecular Function
Desc: Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group.
Synonyms:
  • endonuclease VIII activity
  • GO:0016792
  • phosphodiesterase
Proteins in PDR annotated with:
   This term: 74 [Search]
   Term or descendants: 428 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0008081 - phosphoric diester hydrolase activity (interactive image map)
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