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The series of molecular signals generated as a consequence of activation of the transmembrane Smoothened-type protein in the mesenchymal cells of the prostate that contribute to the progression of the prostate over time. This process contributes to lung development. The series of molecular events whereby information is sent from one location to another within a living organism or between living organisms. The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened in granule cells that contributes to the regulation of proliferation of the cells. The posttranslational modification of members of the Hedgehog family of signaling proteins in order for Hedgehog to exert its biological activity. These modifications include cleavage of its signal sequence, autocatalytic protein cleavage and the attachment of sterol moieties. Grouping of smoothened or patched receptors in a cilium, contributing to the smoothened signaling pathway. The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened resulting in the modulation of the frequency, rate or extent of cardioblast proliferation. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. The series of molecular signals that are initiated by the transmembrane protein Smoothened. In the presence of a Hedgehog signaling molecule, the Patched protein no longer inhibits the activity of Smoothened, and Smoothened signals via the Hedgehog signaling complex to activate downstream components of the Hedgehog signaling pathway. Any process that stops, prevents or reduces the frequency, rate or extent of smoothened signaling. The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened contributing to the dorsal/ventral pattern of the neural tube. The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened. Any process that activates or increases the frequency, rate or extent of smoothened signaling. The series of molecular signals generated as a consequence of activation of the transmembrane Smoothened-type protein. This process contributes to lung development. The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened that results in the spatial identity of regions along the dorsal-ventral axis of the spinal cord. Any process that modulates the frequency, rate or extent of smoothened signaling. The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened that contributes to the progression of a growth plate cartilage chondrocyte over time. Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: smoothened signaling pathway
Acc: GO:0007224
Aspect: Biological Process
Desc: The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened.
Synonyms:
  • hh signalling pathway
  • smoothened signalling pathway
  • hh signaling pathway
  • hedgehog signaling pathway
Proteins in PDR annotated with:
   This term: 102 [Search]
   Term or descendants: 167 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0007224 - smoothened signaling pathway (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle