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Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell that lead to the increased affinity of an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits, for its extracellular ligands. The series of molecular events whereby information is sent from one location to another within a living organism or between living organisms. The entirety of a process whereby information is transmitted. This process begins with the initiation of the signal and ends when a response has been triggered. Any series of molecular signals generated as a consequence of a cytokine or chemokine binding to a cell surface receptor. Any series of molecular signals generated as a consequence of binding to the receptor CD40. The series of molecular signals generated as a consequence of glutamate binding to a cell surface receptor. The series of molecular signals generated by binding of a SLIT protein to a Roundabout (ROBO) family receptor on the surface of the target cell. The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened. The process whereby a signal is passed on from a receptor at the cell surface to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell capable of activating, perpetuating, or inhibiting an immune response. The series of molecular signals initiated by binding of an extracellular ligand to the Toll receptor on the surface of the target cell. The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell. The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. Any series of molecular signals generated as a consequence of an integrin binding to one of its physiological ligands. The series of molecular signals initiated by binding of peptidoglycan to a receptor on the surface of the target cell and mediated by Imd. The main outcome of the Imd signaling is the production of antimicrobial peptides. A series of molecular signals generated as a consequence of a semaphorin receptor (composed of a plexin and a neurophilin) binding to a semaphorin ligand. The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state. The series of molecular signals generated in response to detection of lipopolysaccharide. Lipopolysaccharides (LPS) are major components of the outer membrane of Gram-negative bacteria, making them prime targets for recognition by the immune system. Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell. Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell, where the receptor possesses catalytic activity or is closely associated with an enzyme such as a protein kinase.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: cell surface receptor linked signaling pathway
Acc: GO:0007166
Aspect: Biological Process
Desc: Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell.
Synonyms:
  • cell surface receptor linked signal transduction
Proteins in PDR annotated with:
   This term: 243 [Search]
   Term or descendants: 7541 [Refine Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0007166 - cell surface receptor linked signaling pathway (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle