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The formation of adhesions that stabilize protrusions at the leading edge of a migrating cell; involves integrin activation, clustering, and the recruitment of structural and signaling components to nascent adhesions. The formation of a cell surface protrusion, such as a lamellipodium or filopodium, at the leading edge of a migrating cell. The orderly movement of a cell from one site to another, often during the development of a multicellular organism or multicellular structure. The disassembly of adhesions at the front and rear of a migrating cell. At the leading edge, adhesion disassembly accompanies the formation of new protrusions; at the cell rear, it promotes tail retraction. Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another. The orderly movement of a cell from one site to another along a substrate such as the extracellular matrix; the migrating cell forms a protrusion that attaches to the substrate. The translocation of the cell body forward during cell migration, mediated by tractional force on its substrate and tension in the cortical cytoskeleton. Adhesions transmit propulsive forces and serve as traction points over which the cell moves. The process where neuronal precursors migrate tangentially in the cerebral cortex, primarily guided through physical cell-cell interactions.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: substrate-bound cell migration
Acc: GO:0006929
Aspect: Biological Process
Desc: The orderly movement of a cell from one site to another along a substrate such as the extracellular matrix; the migrating cell forms a protrusion that attaches to the substrate.
Proteins in PDR annotated with:
   This term: 7 [Search]
   Term or descendants: 29 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0006929 - substrate-bound cell migration (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle