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The process whereby phagocytes engulf external particulate material. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles. Phagocytosis occurring as the result of a ligand binding an immune response cell surface activating receptor. The recognition and removal of an apoptotic cell by a neighboring cell or by a phagocyte. The process by which a phagosome, a vesicle formed by phagocytosis, fuses with a lysosome. The initial step in phagocytosis involving adhesion to bacteria, immune complexes and other particulate matter, or an apoptotic cell and based on recognition of factors such as bacterial cell wall components, opsonins like complement and antibody or protein receptors and lipids like phosphatidyl serine, and leading to intracellular signaling in the phagocytosing cell. The internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis, including the membrane and cytoskeletal processes required, which involves one of three mechanisms: zippering of pseudopods around a target via repeated receptor-ligand interactions, sinking of the target directly into plasma membrane of the phagocytosing cell, or induced uptake via an enhanced membrane ruffling of the phagocytosing cell similar to macropinocytosis. A type of vesicle-mediated transport in which cells take up external materials or membrane constituents by the invagination of small region of the plasma membrane to form a new membrane-bounded vesicle. Any process that modulates the frequency, rate or extent of phagocytosis, the process whereby phagocytes engulf external particulate material. Any process that stops, prevents or reduces the frequency, rate or extent of phagocytosis. Any process that activates or increases the frequency, rate or extent of phagocytosis. The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. The infolding of a membrane, resulting in formation of a vesicle. The process by which a microorganism (or other particulate material) is rendered more susceptible to phagocytosis by coating with an opsonin, a blood serum protein such as a complement component or antibody.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: phagocytosis
Acc: GO:0006909
Aspect: Biological Process
Desc: The process whereby phagocytes engulf external particulate material. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles.
Proteins in PDR annotated with:
   This term: 193 [Search]
   Term or descendants: 658 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0006909 - phagocytosis (interactive image map)
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