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Any process that modulates the frequency, rate or extent of the proteolytic cleavage of transmembrane proteins and release of their ectodomain (extracellular domain). Any process that activates or increases the frequency, rate or extent of membrane protein ectodomain peptidolysis. Any process that stops, prevents or reduces the frequency, rate or extent of membrane protein ectodomain proteolysis. The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells. The proteolytic cleavage of a transmembrane protein leading to the release of its intracellular or ecto-domains. The proteolytic cleavage of transmembrane proteins and release of their ectodomain that occurs constantly, regardless of environmental conditions or demands. The proteolytic cleavage of transmembrane proteins and release of their ectodomain that occurs after induction by phorbol-12-myristate-13-acetate (PMA), a protein kinase C agonist. The proteolytic cleavage of transmembrane proteins and release of their ectodomain (extracellular domain).

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: membrane protein ectodomain proteolysis
Acc: GO:0006509
Aspect: Biological Process
Desc: The proteolytic cleavage of transmembrane proteins and release of their ectodomain (extracellular domain).
Synonyms:
  • membrane protein solubilization
  • receptor shedding
Proteins in PDR annotated with:
   This term: 22 [Search]
   Term or descendants: 38 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0006509 - membrane protein ectodomain proteolysis (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle