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The maintenance of chromatin in a transciptionally silent state such as heterochromatin. The initial formation of a transcriptionally silent chromatin structure such as heterochromatin. Repression of transcription by altering the structure of chromatin, e.g. by conversion of large regions of DNA into an inaccessible state often called heterochromatin. Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. Repression of transcription of telomeric DNA by altering the structure of chromatin. Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. Repression of transcription by methylation of DNA, leading to the formation of heterochromatin. Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving RNA. Repression of transcription at silent mating-type loci by alteration of the structure of chromatin. Any transcriptional or post-transcriptional process carried out at the cellular level that results in long-term gene inactivation. Repression of transcription by conversion of large regions of DNA into heterochromatin, directed by small RNAs sharing sequence identity to the repressed region. The cellular synthesis of RNA on a template of DNA. Repression of transcription of ribosomal DNA by altering the structure of chromatin. Any epigenetic process that stops, prevents or reduces the rate of gene expression. Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic heterochromatin and contributes to chromatin silencing. Repression of transcription of centromeric DNA by altering the structure of chromatin. Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form. Any process that affects the rate, extent or location of chromatin silencing. Any process that modulates the frequency, rate or extent of gene expression; the process is mitotically or meiotically heritable, or is stably self-propagated in the cytoplasm of a resting cell, and does not entail a change in DNA sequence. Any cellular process that stops, prevents or reduces the frequency, rate or extent of transcription. Any process that stops, prevents or reduces the frequency, rate or extent of cellular DNA-dependent transcription. Any process that activates or increases the frequency, rate or extent of chromatin silencing. Any process that stops, prevents or reduces the frequency, rate or extent of chromatin silencing.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: chromatin silencing
Acc: GO:0006342
Aspect: Biological Process
Desc: Repression of transcription by altering the structure of chromatin, e.g. by conversion of large regions of DNA into an inaccessible state often called heterochromatin.
Synonyms:
  • chromatin-mediated maintenance of transcriptional inactivation
  • TGS
  • chromatin-mediated silencing
  • heterochromatic silencing
  • transcriptional gene silencing
  • GO:0016440
Proteins in PDR annotated with:
   This term: 152 [Search]
   Term or descendants: 398 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0006342 - chromatin silencing (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle