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Modulates the rate of NTP hydrolysis by a NTPase. Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. Stimulates the exchange of guanyl nucleotides associated with the GTPase ARF. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. Stimulates the exchange of guanyl nucleotides associated with a GTPase; dependent on the presence of a cyclic nucleotide. Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Sar family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Ras superfamily. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. Modulates the rate of GTP hydrolysis by a GTPase.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: guanyl-nucleotide exchange factor activity
Acc: GO:0005085
Aspect: Molecular Function
Desc: Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
Synonyms:
  • GNRP
  • GO:0019839
  • GEF
  • GO:0008433
  • guanyl-nucleotide release factor activity
  • guanyl-nucleotide releasing factor
Proteins in PDR annotated with:
   This term: 392 [Search]
   Term or descendants: 715 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0005085 - guanyl-nucleotide exchange factor activity (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle