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Modulates the rate of NTP hydrolysis by a NTPase. Interacting selectively and non-covalently with Rab protein, any member of the Rab subfamily of the Ras superfamily of monomeric GTPases. Increases the rate of GTP hydrolysis by a GTPase of the Sar family. Increases the rate of GTP hydrolysis by a GTPase of the Ras superfamily. Stimulates the exchange of guanyl nucleotides associated with the GTPase ARF. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. Increases the rate of GTP hydrolysis by the GTPase ARF. Modulates the rate of GTP hydrolysis by a small monomeric GTPase. The binding activity of a molecule that brings together a guanyl-nucleotide exchange factor and one or more other molecules, permitting them to function in a coordinated way. Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Sar family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. null Prevents the dissociation of GDP from a GTPase, thereby preventing GTP from binding. Modulates the rate of GTP hydrolysis by a GTPase. Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Ras superfamily. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: small GTPase regulator activity
Acc: GO:0005083
Aspect: Molecular Function
Desc: Modulates the rate of GTP hydrolysis by a small monomeric GTPase.
Synonyms:
  • small GTPase regulatory/interacting protein activity
Proteins in PDR annotated with:
   This term: 113 [Search]
   Term or descendants: 1228 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0005083 - small GTPase regulator activity (interactive image map)
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