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Combining with calcitonin to initiate a change in cell activity. Combining with the corticotrophin-releasing factor family of ligands, including the urocortins, to initiate a change in cell activity. Combining with secretin to initiate a change in cell activity. A G-protein coupled receptor that binds glutamate and inhibits adenylate cyclase activity. null Combining with soluble compounds to initiate a change in cell activity. These receptors are responsible for the sense of taste. Combining with growth hormone-releasing hormone to initiate a change in cell activity. Combining with an extracellular or intracellular peptide to initiate a G-protein mediated change in cell activity. A G-protein is a signal transduction molecule that alternates between an inactive GDP-bound and an active GTP-bound state. Combining with glucagon to initiate a change in cell activity. Combining with cannabinoids to initiate a change in cell activity. Combining with a protein hormone to initiate a change in cell activity. Combining with gastric inhibitory peptide to initiate a change in cell activity. Combining with platelet activating factor to initiate a change in cell activity. Combining with parathyroid hormone to initiate a change in cell activity. Combining with vasoactive intestinal polypeptide to initiate a change in cell activity. Combining with thyrotropin-releasing hormone to initiate a change in cell activity. null Combining with an extracellular or intracellular messenger to initiate a change in cell activity. Combining with nicotinic acid to initiate a change in cell activity. A receptor that binds an extracellular amine and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. null A G-protein coupled receptor that interacts with pituitary adenylate cyclase-activating polypeptide. Combining with a cytokinin to initiate a change in cell activity. The receptor is G-protein coupled. A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. Combining with an icosanoid to initiate a change in cell activity. Combining with a leukotriene to initiate a change in cell activity. Leukotrienes are pharmacologically active substances with a set of three conjugated double bonds; some contain a peptide moiety based on cysteine. Combining with ecdysis-triggering hormone to initiate a change in cell activity. A G-protein coupled receptor that responds to incidental electromagnetic radiation, particularly visible light. null Combining with airborne compounds to initiate a change in cell activity. These receptors are used for the sense of smell. Combining with a pheromone to initiate a change in cell activity. null A GPCR that binds a nucleotide or nucleotide derivative as its ligand. null Combining with melatonin, N-acetyl-5-methoxytryptamine, to initiate a change in cell activity. Melatonin is a neuroendocrine substance that stimulates the aggregation of melanosomes in melanophores, thus lightening the skin. null null null null null Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: G-protein coupled receptor activity
Acc: GO:0004930
Aspect: Molecular Function
Desc: A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers.
Synonyms:
  • GO:0016526
  • GPCR activity
  • orphan GPCR activity
  • G-protein-coupled receptor activity
  • orphan G protein coupled receptor activity
  • orphan G-protein coupled receptor activity
  • G-protein coupled receptor activity, unknown ligand
  • G protein coupled receptor activity
  • G-protein linked receptor activity
  • ligand-dependent GPCR activity
  • G protein linked receptor activity
Proteins in PDR annotated with:
   This term: 1795 [Search]
   Term or descendants: 3770 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0004930 - G-protein coupled receptor activity (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle