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Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate. Catalysis of the reaction: ATP + detyrosinated alpha-tubulin + L-tyrosine = alpha-tubulin + ADP + phosphate. Catalysis of the ligation of two substances via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: tubulin-tyrosine ligase activity
Acc: GO:0004835
Aspect: Molecular Function
Desc: Catalysis of the reaction: ATP + detyrosinated alpha-tubulin + L-tyrosine = alpha-tubulin + ADP + phosphate.
Synonyms:
  • alpha-tubulin:L-tyrosine ligase (ADP-forming)
  • tubulinyl-tyrosine ligase activity
  • TTL activity
Proteins in PDR annotated with:
   This term: 53 [Search]
   Term or descendants: 53 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0004835 - tubulin-tyrosine ligase activity (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle