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Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. Catalysis of the oxidative decarboxylation of pyruvate. Catalysis of the reaction: pyruvate + ferricytochrome b1 + H2O = CO2 + acetate + ferrocytochrome b1. Catalysis of the reaction: pyruvate + lipoamide = S-acetyldihydrolipoamide + CO2. Catalysis of the reaction: pyruvate + CoA + NAD(P)+ = acetyl-CoA + CO2 + NAD(P)H.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: pyruvate dehydrogenase activity
Acc: GO:0004738
Aspect: Molecular Function
Desc: Catalysis of the oxidative decarboxylation of pyruvate.
Synonyms:
  • pyruvic dehydrogenase activity
  • pyruvic acid dehydrogenase activity
Proteins in PDR annotated with:
   This term: 10 [Search]
   Term or descendants: 56 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0004738 - pyruvate dehydrogenase activity (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle