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Catalysis of the hydrolysis of a pyrophosphate bond between two phosphate groups, leaving one phosphate on each of the two fragments. Catalysis of the reaction: FAD + H2O = AMP + FMN. Catalysis of the hydrolysis of P(1),P(4)-bis(5'-nucleosyl)tetraphosphate into two nucleotides. Catalysis of the reaction: NAD+ + H2O = AMP + NMN. Catalysis of the reaction: P1-P6-bis(5'-adenosyl) pentaphosphate + H2O = AMP + adenosine 5'-tetraphosphate. Catalysis of the reaction: a dinucleotide + H2O = 2 mononucleotides. Catalysis of the reaction: P1-P3-bis(5'-adenosyl) triphosphate + H2O = ADP + AMP. Catalysis of the reaction: P1-P6-bis(5'-adenosyl) hexaphosphate + H2O = AMP + adenosine 5'-pentaphosphate. Catalysis of the reaction: NADH (nicotinamide adenine dinucleotide (reduced)) + H2O = AMP + NMNH (nicotinamide mononucleotide (reduced)). Catalysis of the reaction: NADPH + H20 = NMNH + ADP. Catalysis of the hydrolysis of any acid anhydride which contains phosphorus.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: nucleotide diphosphatase activity
Acc: GO:0004551
Aspect: Molecular Function
Desc: Catalysis of the reaction: a dinucleotide + H2O = 2 mononucleotides.
Synonyms:
  • dinucleotide nucleotidohydrolase activity
  • nucleotide-sugar pyrophosphatase activity
  • nucleotide pyrophosphatase activity
Proteins in PDR annotated with:
   This term: 16 [Search]
   Term or descendants: 64 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0004551 - nucleotide diphosphatase activity (interactive image map)
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Created and Maintained by: Michael Riffle