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Catalysis of the endonucleolytic cleavage of RNA with 5'-phosphomonoesters and 3'-OH termini; makes two staggered cuts in both strands of dsRNA, leaving a 3' overhang of 2 nt. Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters. Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks to yield 5'-phosphomonoesters. Catalysis of the digestion of double-stranded RNAs into 20 to 30-nucleotide products. These products typically associate to the RNA-induced silencing complex and serve as guide RNAs for posttranslational RNA interference. Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: ribonuclease III activity
Acc: GO:0004525
Aspect: Molecular Function
Desc: Catalysis of the endonucleolytic cleavage of RNA with 5'-phosphomonoesters and 3'-OH termini; makes two staggered cuts in both strands of dsRNA, leaving a 3' overhang of 2 nt.
Synonyms:
  • RNase III activity
  • pre-mRNA 3'-end processing endonuclease
  • ribonuclease 3 activity
Proteins in PDR annotated with:
   This term: 70 [Search]
   Term or descendants: 71 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0004525 - ribonuclease III activity (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle