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Catalysis of the hydrolysis of ester linkages within nucleic acids. Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid. Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks. Catalysis of the hydrolysis of ester linkages at specific sites within a deoxyribonucleic acid molecule by creating internal breaks. Catalysis of endonucleolytic cleavage of DNA in a site-specific manner, resulting in double-strand breaks. Catalysis of the removal of pyrimidine dimers by removing the 5' pyrimidine of the dimer by cleaving the N-C1' glycosidic bond between the 5' pyrimidine of the dimer and the deoxyribose sugar. The reaction releases the 5' pyrimidine of the dimer and leaves an apurinic (AP) site. The reaction involves the formation of a covalent enzyme substrate intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apyrimidinic (AP) site. Catalysis of the hydrolysis of ester linkages within a single-stranded deoxyribonucleic acid molecule by creating internal breaks. Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks. Catalysis of the cleavage of a flap structure in DNA, but not other DNA structures; processes the ends of Okazaki fragments in lagging strand DNA synthesis. Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters. Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid at sites flanking regions of damaged DNA to which the Uvr ABC excinuclease complexes bind. Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acids by creating internal breaks to yield 3'-phosphomonoesters.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: endodeoxyribonuclease activity
Acc: GO:0004520
Aspect: Molecular Function
Desc: Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks.
Synonyms:
  • DNA nicking activity
  • endonuclease G activity
Proteins in PDR annotated with:
   This term: 34 [Search]
   Term or descendants: 211 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0004520 - endodeoxyribonuclease activity (interactive image map)
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