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Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. Catalysis of the reaction: L-tryptophan + tetrahydrobiopterin + O2 = 5-hydroxy-L-tryptophan + 4-alpha-hydroxytetrahydrobiopterin + H2O. Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor. Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced pteridine and one other donor, and one atom of oxygen is incorporated into one donor.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: tryptophan 5-monooxygenase activity
Acc: GO:0004510
Aspect: Molecular Function
Desc: Catalysis of the reaction: L-tryptophan + tetrahydrobiopterin + O2 = 5-hydroxy-L-tryptophan + 4-alpha-hydroxytetrahydrobiopterin + H2O.
Synonyms:
  • indoleacetic acid-5-hydroxylase activity
  • L-tryptophan hydroxylase activity
  • tryptophan hydroxylase activity
  • L-tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating)
  • tryptophan 5-hydroxylase activity
Proteins in PDR annotated with:
   This term: 13 [Search]
   Term or descendants: 13 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0004510 - tryptophan 5-monooxygenase activity (interactive image map)
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