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Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NAD+ = 5,10-methenyltetrahydrofolate + NADH + H+. Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NAD(P)+ = 5,10-methenyltetrahydrofolate + NAD(P)H + H+. Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces NAD or NADP.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: methylenetetrahydrofolate dehydrogenase (NAD+) activity
Acc: GO:0004487
Aspect: Molecular Function
Desc: Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NAD+ = 5,10-methenyltetrahydrofolate + NADH + H+.
Synonyms:
  • 5,10-methylenetetrahydrofolate:NAD+ oxidoreductase
  • 5,10-methylenetetrahydrofolate dehydrogenase activity
Proteins in PDR annotated with:
   This term: 6 [Search]
   Term or descendants: 6 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0004487 - methylenetetrahydrofolate dehydrogenase (NAD+) activity (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle