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Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate. Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + heparan sulfate = adenosine 3',5'-bisphosphate + heparan sulfate 2-O-sulfate; results in 2-O-sulfation of iduronic acid residues in heparan sulfate. Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + heparan sulfate = adenosine 3',5'-bisphosphate + sulfated heparan sulfate.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: heparan sulfate 2-O-sulfotransferase activity
Acc: GO:0004394
Aspect: Molecular Function
Desc: Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + heparan sulfate = adenosine 3',5'-bisphosphate + heparan sulfate 2-O-sulfate; results in 2-O-sulfation of iduronic acid residues in heparan sulfate.
Synonyms:
  • heparin-sulphate 2-sulphotransferase activity
  • heparan-sulfate 2-O-sulphotransferase activity
  • heparin 2-sulfotransferase activity
Proteins in PDR annotated with:
   This term: 3 [Search]
   Term or descendants: 3 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0004394 - heparan sulfate 2-O-sulfotransferase activity (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle