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Catalysis of the reaction: estradiol-17-beta + NADP+ = estrone + NADPH + H+. Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP, and in which one substrate is a sterol derivative. Catalysis of an oxidation-reduction (redox) reaction in which one substrate is a sterol derivative. Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: estradiol 17-beta-dehydrogenase activity
Acc: GO:0004303
Aspect: Molecular Function
Desc: Catalysis of the reaction: estradiol-17-beta + NADP+ = estrone + NADPH + H+.
Synonyms:
  • estradiol 17beta-dehydrogenase activity
  • 17-beta-estradiol dehydrogenase activity
  • estrogen 17-oxidoreductase activity
  • 17beta-estradiol dehydrogenase activity
  • 17-beta-hydroxysteroid dehydrogenase activity
  • 17beta-hydroxysteroid dehydrogenase activity
  • estradiol dehydrogenase activity
  • 17beta-HSD
  • estradiol-17beta:NAD(P)+ 17-oxidoreductase activity
  • 20alpha-hydroxysteroid dehydrogenase
  • 17beta,20alpha-hydroxysteroid dehydrogenase activity
  • 17-beta-HSD activity
Proteins in PDR annotated with:
   This term: 87 [Search]
   Term or descendants: 87 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0004303 - estradiol 17-beta-dehydrogenase activity (interactive image map)
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