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An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of germline gene segments encoding immunoglobulin superfamily domains, and allowing for enhanced responses upon subsequent exposures to the same antigen (immunological memory). Recombined receptors for antigen encoded by immunoglobulin superfamily domains include T cell receptors and immunoglobulins (antibodies). An example of this is the adaptive immune response found in Mus musculus. Any process that activates or increases the frequency, rate, or extent of germinal center formation. Any process that activates or increases the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata. Any process that modulates the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata. The process by which germinal centers form. A germinal center is a specialized microenvironment formed when activated B cells enter lymphoid follicles. Germinal centers are the foci for B cell proliferation and somatic hypermutation. Any process that activates or increases the frequency, rate, or extent of an adaptive immune response. Any process that modulates the frequency, rate, or extent of germinal center formation.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: positive regulation of germinal center formation
Acc: GO:0002636
Aspect: Biological Process
Desc: Any process that activates or increases the frequency, rate, or extent of germinal center formation.
Synonyms:
  • activation of germinal center formation
  • up-regulation of germinal center formation
  • upregulation of germinal center formation
  • stimulation of germinal center formation
  • up regulation of germinal center formation
Proteins in PDR annotated with:
   This term: 7 [Search]
   Term or descendants: 7 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0002636 - positive regulation of germinal center formation (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle