YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

The process by which immune receptor genes are diversified through recombination of the germline genetic elements within a single genetic locus. The addition of variable numbers of random nucleotides by terminal deoxytransferase in the N regions of heavy chain immunoglobulin genes. N regions are found at the V-D and D-J recombinational junctions. The process by which immunoglobulin genes are formed through recombination of the germline genetic elements, as known as immunoglobulin gene segments, within a single locus. The somatic process allowing for the production of immune receptors whose specificity is not encoded in the germline genomic sequences. The addition of variable numbers of random nucleotides by terminal deoxytransferase in the N regions of heavy chain immunoglobulin and T cell receptor genes. N regions are found at the V-D, D-D, V-J, and D-J recombinational junctions, depending on the immune receptor gene. The somatic process by means of which sequence diversity of immunoglobulins is generated. The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: somatic diversification of immunoglobulin genes by N region addition
Acc: GO:0002570
Aspect: Biological Process
Desc: The addition of variable numbers of random nucleotides by terminal deoxytransferase in the N regions of heavy chain immunoglobulin genes. N regions are found at the V-D and D-J recombinational junctions.
Synonyms:
  • somatic diversification of antibody genes by N region addition
Proteins in PDR annotated with:
   This term: 0
   Term or descendants: 0


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0002570 - somatic diversification of immunoglobulin genes by N region addition (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle