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The hydrolysis of a peptide bond or bonds within a protein as part of protein maturation, the process leading to the attainment of the full functional capacity of a protein. Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway. Inflammation which comprises a rapid, short-lived, relatively uniform response to acute injury or antigenic challenge and is characterized by accumulations of fluid, plasma proteins, and granulocytic leukocytes. An acute inflammatory response occurs within a matter of minutes or hours, and either resolves within a few days or becomes a chronic inflammatory response. The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages. Any protein maturation process achieved by the cleavage of peptide bonds. Any process that activates Factor XII (Hageman factor). Factor XII is a protein synthesized by the liver that circulates in an inactive form until it encounters collagen or basement membrane or activated platelets (as occurs at the site of endothelial injury). Factor XII then undergoes a conformational change (becoming factor XIIa), exposing an active serine center that can subsequently cleave protein substrates and activate a variety of mediator systems. Factor XII is a participant in the clotting cascade as well as the kinin cascade. Any process activating plasma proteins by proteolysis as part of an acute inflammatory response.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: activation of plasma proteins involved in acute inflammatory response
Acc: GO:0002541
Aspect: Biological Process
Desc: Any process activating plasma proteins by proteolysis as part of an acute inflammatory response.
Proteins in PDR annotated with:
   This term: 2 [Search]
   Term or descendants: 95 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0002541 - activation of plasma proteins involved in acute inflammatory response (interactive image map)
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