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The change in morphology and behavior of a mature or immature B cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. The process whereby a precursor cell type acquires the specialized features of a B cell. The process whereby transitional stage B cells acquire the specialized features of mature B cells in the spleen. The process whereby a relatively unspecialized precursor cell acquires specialized features of B cells, T cells, or natural killer cells. The process whereby a hemopoietic stem cell acquires the specialized features of a B-1 B cell. B-1 B cells are a distinct subset of B cells characterized as being CD5 positive, found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity. The process whereby a nave B cell acquires the specialized features of a mature or memory B cell during an immune response.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: mature B cell differentiation
Acc: GO:0002335
Aspect: Biological Process
Desc: The process whereby transitional stage B cells acquire the specialized features of mature B cells in the spleen.
Synonyms:
  • mature B-cell differentiation
  • mature B-lymphocyte differentiation
  • mature B lymphocyte differentiation
Proteins in PDR annotated with:
   This term: 1 [Search]
   Term or descendants: 8 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0002335 - mature B cell differentiation (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle