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The process by which immune receptor genes are diversified through recombination of the germline genetic elements within a single genetic locus. The somatic process by means of which sequence diversity of immunoglobulins is generated after the induction of an immune response. The process by which immunoglobulin genes are formed through recombination of the germline genetic elements, also known as immunoglobulin gene segments, within a single locus following the induction of an immune response. The switching of activated B cells from IgM biosynthesis to biosynthesis of other isotypes of immunoglobulin, accomplished through a recombination process involving an intrachromosomal deletion involving switch regions that reside 5' of each constant region gene segment in the immunoglobulin heavy chain locus. The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus during an immune response, resulting in an increase in its intracellular or extracellular levels. The process by which immunoglobulin genes are formed through recombination of the germline genetic elements, as known as immunoglobulin gene segments, within a single locus. The somatic process by means of which sequence diversity of immunoglobulins is generated.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: somatic recombination of immunoglobulin genes during immune response
Acc: GO:0002204
Aspect: Biological Process
Desc: The process by which immunoglobulin genes are formed through recombination of the germline genetic elements, also known as immunoglobulin gene segments, within a single locus following the induction of an immune response.
Synonyms:
  • somatic recombination of antibody genes during immune response
Proteins in PDR annotated with:
   This term: 3 [Search]
   Term or descendants: 46 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0002204 - somatic recombination of immunoglobulin genes during immune response (interactive image map)
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