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The somatic process allowing for the production of immune receptors whose specificity is not encoded in the germline genomic sequences. The addition of variable numbers of random nucleotides by terminal deoxytransferase in the N regions of heavy chain immunoglobulin and T cell receptor genes. N regions are found at the V-D, D-D, V-J, and D-J recombinational junctions, depending on the immune receptor gene. The somatic process by means of which sequence diversity of immunoglobulins is generated. The somatic process by means of which sequence diversity of the DSCAM-based immune receptors of insects is generated. The process by means of which sequence diversity of the FREP-based immune receptors of snails is generated. The somatic process by means of which sequence diversity of T cell receptor genes is generated. The process by which immune receptor genes are diversified through gene conversion. The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process. The process by which immune receptor genes are diversified through somatic mutation. The process by which immune receptor genes are diversified through recombination of the germline genetic elements within a single genetic locus. Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end. The process by which immune receptor genes are diversified through alternate splicing. The somatic process by means of which sequence diversity of the variable lymphocyte receptors (VLR) of jawless fish is generated. The process whose specific outcome is the progression of an organismal system whose objective is to provide calibrated responses by an organism to a potential internal or invasive threat, over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process. Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: somatic diversification of immune receptors
Acc: GO:0002200
Aspect: Biological Process
Desc: The somatic process allowing for the production of immune receptors whose specificity is not encoded in the germline genomic sequences.
Proteins in PDR annotated with:
   This term: 0
   Term or descendants: 75 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0002200 - somatic diversification of immune receptors (interactive image map)
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