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Any process that stops, prevents or reduces the frequency, rate or extent of complement activation. Any process that modulates the frequency, rate or extent of complement activation. Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway. The activation of the membrane attack complex components of the complement cascade which can result in death of a target cell through cytolysis. Any process that stops, prevents or reduces the frequency, rate or extent of the activation of the membrane attack complex components of the complement cascade. Any process that decreases the rate, frequency or extent of protein maturation by peptide bond cleavage. Any process that modulates the frequency, rate or extent of the activation of the membrane attack complex components of the complement cascade. Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune effector process. Any process that stops, prevents, or reduces the frequency, rate, or extent of a humoral immune response.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: negative regulation of activation of membrane attack complex
Acc: GO:0001971
Aspect: Biological Process
Desc: Any process that stops, prevents or reduces the frequency, rate or extent of the activation of the membrane attack complex components of the complement cascade.
Synonyms:
  • negative regulation of activation of the terminal complement cascade
  • negative regulation of membrane attack complex assembly
  • negative regulation of MAC assembly
  • negative regulation of MAC formation
  • down-regulation of activation of membrane attack complex
  • negative regulation of activation of terminal complement complex
  • negative regulation of membrane attack complex formation
  • down regulation of activation of membrane attack complex
  • inhibition of activation of membrane attack complex
  • negative regulation of activation of TCC
  • downregulation of activation of membrane attack complex
  • negative regulation of activation of MAC
Proteins in PDR annotated with:
   This term: 1 [Search]
   Term or descendants: 1 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0001971 - negative regulation of activation of membrane attack complex (interactive image map)
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Created and Maintained by: Michael Riffle