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Any process that stops, prevents or reduces the frequency, rate or extent of a signaling pathway. Any process that modulates the frequency, rate or extent of a signaling pathway. The series of molecular events whereby information is sent from one location to another within a living organism or between living organisms. Any series of molecular signals generated as a consequence of a cytokine or chemokine binding to a cell surface receptor. Any process that modulates the frequency, rate or extent of signal transduction. Any process that decreases the rate or extent of the tumor necrosis factor-mediated signaling pathway. The tumor necrosis factor-mediated signaling pathway is the series of molecular signals generated as a consequence of tumor necrosis factor binding to a cell surface receptor. Any process that stops, prevents or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule. Any process that decreases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. Any process that modulates the frequency, rate or extent of the cytokine mediated signaling pathway. Any process that decreases the rate, frequency or extent of the series of molecular events generated as a consequence of interferon-gamma binding to a cell surface receptor. Any process that stops, prevents or reduces the frequency, rate or extent of the cytokine mediated signaling pathway. Any process that decreases the rate, frequency or extent of the series of molecular events generated as a consequence of a chemokine binding to a cell surface receptor. Any process that decreases the rate, frequency or extent of a type I interferon-mediated signaling pathway. A type I interferon-mediated signaling pathway is the series of molecular events generated as a consequence of a type I interferon binding to a cell surface receptor. Any process that decreases the rate, frequency or extent of the series of molecular events generated as a consequence of interleukin-6 binding to a cell surface receptor. Any process that decreases the rate, frequency or extent of the series of molecular events generated as a consequence of interleukin-35 binding to a cell surface receptor. Any process that decreases the rate, frequency or extent of the series of molecular events generated as a consequence of interleukin-27 binding to a cell surface receptor. Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell. The process whereby a protein/peptide signal causes activation of a receptor.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: negative regulation of cytokine-mediated signaling pathway
Acc: GO:0001960
Aspect: Biological Process
Desc: Any process that stops, prevents or reduces the frequency, rate or extent of the cytokine mediated signaling pathway.
Synonyms:
  • negative regulation of cytokine mediated signaling pathway
  • negative regulation of cytokine and chemokine mediated signaling pathway
  • negative regulation of cytokine mediated signalling pathway
  • down regulation of cytokine mediated signaling pathway
  • down-regulation of cytokine mediated signaling pathway
  • downregulation of cytokine mediated signaling pathway
  • inhibition of cytokine mediated signaling pathway
Proteins in PDR annotated with:
   This term: 19 [Search]
   Term or descendants: 28 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0001960 - negative regulation of cytokine-mediated signaling pathway (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle