YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

The directed killing of a target cell by a leukocyte. Any process that modulates the frequency, rate, or extent of antibody-dependent cellular cytotoxicity. Any process of the immune system that occurs as part of an immune response. Any process that activates or increases the frequency, rate or extent of cell death by apoptosis. Any process in an organism that results in the killing of its own cells or those of another organism, including in some cases the death of the other organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions. An inflammatory response resulting in cell death mediated by activation of the classical complement pathway or induction of effector cell phagocytosis or cytolysis mechanisms via complement or Fc receptors following the binding of antibodies to cell surface antigens on a target cell. An inflammatory response resulting in cell death or dysfunction mediated by activation of the classical complement pathway or induction of effector cell phagocytosis, cytolysis mechanisms via complement or Fc receptors following the binding of antibodies to cell surface antigens on a target cell, or mediated by the direct binding of antibody to cellular receptors. A process that directly activates any of the steps required for cell death by apoptosis. A process which directly activates any of the steps required for programmed cell death. Any process that stops, prevents, or reduces the rate of antibody-dependent cellular cytotoxicity. Cytolysis of target cells by natural killer cells, eosinophils, neutrophils, monocytes, or macrophages following engagement of antibodies bound to the target cells by Fc receptors on the effector cells. Any process that activates or increases the frequency, rate or extent of antibody-dependent cellular cytotoxicity.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: antibody-dependent cellular cytotoxicity
Acc: GO:0001788
Aspect: Biological Process
Desc: Cytolysis of target cells by natural killer cells, eosinophils, neutrophils, monocytes, or macrophages following engagement of antibodies bound to the target cells by Fc receptors on the effector cells.
Synonyms:
  • antibody dependent cell death
  • type VI hypersensitivity
  • antibody-dependent cell death
  • antibody dependent cell killing
  • ADCC
  • antibody-dependent cell killing
Proteins in PDR annotated with:
   This term: 6 [Search]
   Term or descendants: 6 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0001788 - antibody-dependent cellular cytotoxicity (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle