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Progressive reduction in length of the telomeres, the termini of eukaryotic chromosomes, that occurs as part of the cellular aging process. Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and the length of telomeric DNA. These processes includes those that shorten and lengthen the telomeric DNA sequences. Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and shortening the telomeric DNA. The chromatin modification process that occurs during the lifespan of the cell that results in changes in chromatin structure. Such changes may lead to gene dysregulation and ultimately to a loss in cell homeostasis, bringing about an aging phenotype. The process associated with progression of the cell from its inception to the end of its lifespan that occurs as the cell continues cycles of growth and division. The process by which changes in chromatin structure contributing to replicative cell aging occurs.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: age-dependent telomere shortening
Acc: GO:0001309
Aspect: Biological Process
Desc: Progressive reduction in length of the telomeres, the termini of eukaryotic chromosomes, that occurs as part of the cellular aging process.
Proteins in PDR annotated with:
   This term: 1 [Search]
   Term or descendants: 1 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0001309 - age-dependent telomere shortening (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle