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The process, which occurs as a dividing cell ages, leading to expression of genes that are typically not expressed due to silencing by regulatory proteins. The process leading to expression of genes that are typically not expressed due to silencing by regulatory proteins. The chromatin modification process that occurs during the lifespan of the cell that results in changes in chromatin structure. Such changes may lead to gene dysregulation and ultimately to a loss in cell homeostasis, bringing about an aging phenotype. The process associated with progression of the cell from its inception to the end of its lifespan that occurs as the cell continues cycles of growth and division. The process by which changes in chromatin structure contributing to replicative cell aging occurs. Any process that stops, prevents or reduces the frequency, rate or extent of chromatin silencing.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: loss of chromatin silencing involved in replicative cell aging
Acc: GO:0001308
Aspect: Biological Process
Desc: The process, which occurs as a dividing cell ages, leading to expression of genes that are typically not expressed due to silencing by regulatory proteins.
Synonyms:
  • loss of chromatin silencing during replicative cell ageing
Proteins in PDR annotated with:
   This term: 13 [Search]
   Term or descendants: 13 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0001308 - loss of chromatin silencing involved in replicative cell aging (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle