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The process, which occurs as a dividing cell ages, leading to expression of genes that are typically not expressed due to silencing by regulatory proteins. Progressive reduction in length of the telomeres, the termini of eukaryotic chromosomes, that occurs as part of the cellular aging process. Progression of the cell from its inception to the end of its lifespan. The chromatin modification process that occurs during the lifespan of the cell that results in changes in chromatin structure. Such changes may lead to gene dysregulation and ultimately to a loss in cell homeostasis, bringing about an aging phenotype. The process associated with progression of the cell from its inception to the end of its lifespan that occurs as the cell continues cycles of growth and division. The process by which changes in chromatin structure contributing to replicative cell aging occurs. Increase in abundance of circular DNA molecules in dividing cells as they age. These molecules originate in the chromosome but are excised and circularized, often by intramolecular homologous recombination between direct tandem repeats, and then replicated independently of chromosomal replication. The alteration of DNA or protein in chromatin, which may result in changing the chromatin structure.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: progressive alteration of chromatin involved in replicative cell aging
Acc: GO:0001304
Aspect: Biological Process
Desc: The process by which changes in chromatin structure contributing to replicative cell aging occurs.
Synonyms:
  • progressive alteration of chromatin during replicative cell ageing
  • progressive alteration of chromatin during replicative cell aging
Proteins in PDR annotated with:
   This term: 0
   Term or descendants: 15 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0001304 - progressive alteration of chromatin involved in replicative cell aging (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle