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A nuclear telomere cap complex that is formed by the association of telomeric ssDNA- and dsDNA-binding proteins with telomeric DNA, and is involved in telomere protection and recruitment of telomerase. The complex contains TRF1, TRF2, POT1, RAP1, TIN2 and TPP1 in mammalian cells, and Pot1, Tpz1, Ccq1, Poz1, and Rap1 in Schizosaccharomyces. Taz1 and Rap1 (or their mammalian equivalents) form a dsDNA-binding subcomplex, Pot1 and Tpz1 form an ssDNA-binding subcomplex, and the two subcomplexes are bridged by Poz1. The terminal region of a linear chromosome that includes the telomeric DNA repeats and associated proteins. A nuclear telomere cap complex that is formed by the association of the Stn1 and Ten1 proteins with telomeric DNA; in some species a third protein is present. A complex of DNA and protein located at the end of a linear chromosome that protects and stabilizes a linear chromosome. Any constituent part of a nuclear chromosome, a chromosome found in the nucleus of a eukaryotic cell. A macromolecular complex containing both protein and DNA molecules. Any constituent part of the nucleus, a membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. Any constituent part of a chromosome, a structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. A chromosome found in the nucleus of a eukaryotic cell. The terminal region of a linear chromosome in the nucleus that includes the telomeric DNA repeats and associated proteins. A complex of DNA and protein located at the end of a linear chromosome in the nucleus that protects and stabilizes a linear chromosome.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: nuclear telomere cap complex
Acc: GO:0000783
Aspect: Cellular Component
Desc: A complex of DNA and protein located at the end of a linear chromosome in the nucleus that protects and stabilizes a linear chromosome.
Proteins in PDR annotated with:
   This term: 21 [Search]
   Term or descendants: 29 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0000783 - nuclear telomere cap complex (interactive image map)
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