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The chemical reactions and pathways resulting in the breakdown of a macromolecule, any large molecule including proteins, nucleic acids and carbohydrates, as carried out by individual cells. The cellular DNA metabolic process resulting in the breakdown of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one. The removal of nonhomologous sequences at the broken 3' single-strand DNA end before DNA repair synthesis can occur. The cleavage of DNA during apoptosis, which usually occurs in two stages: cleavage into fragments of about 50 kbp followed by cleavage between nucleosomes to yield 200 bp fragments. Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. The chemical reactions and pathways resulting in the breakdown of DNA, involving the hydrolysis of internal 3',5'-phosphodiester bonds in one or two strands of deoxyribonucleotides.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: DNA catabolic process, endonucleolytic
Acc: GO:0000737
Aspect: Biological Process
Desc: The chemical reactions and pathways resulting in the breakdown of DNA, involving the hydrolysis of internal 3',5'-phosphodiester bonds in one or two strands of deoxyribonucleotides.
Synonyms:
  • endonucleolytic DNA catabolism
  • DNA breakdown, endonucleolytic
  • DNA degradation, endonucleolytic
  • endonucleolytic degradation of DNA
Proteins in PDR annotated with:
   This term: 2 [Search]
   Term or descendants: 55 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0000737 - DNA catabolic process, endonucleolytic (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle