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Repair of a DSB made between two repeated sequences oriented in the same direction occurs primarily by the single strand annealing pathway. The ends of the break are processed by a 5' to 3' exonuclease, exposing complementary single-strand regions of the direct repeats that can anneal, resulting in a deletion of the unique DNA between the direct repeats. The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. A DNA repair process in which that does not require the exchange of genetic material between the broken DNA molecule and a homologous region of DNA. The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends. A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: non-recombinational repair
Acc: GO:0000726
Aspect: Biological Process
Desc: A DNA repair process in which that does not require the exchange of genetic material between the broken DNA molecule and a homologous region of DNA.
Proteins in PDR annotated with:
   This term: 0
   Term or descendants: 103 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0000726 - non-recombinational repair (interactive image map)
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