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Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide. Formation of a catalytic spliceosome complex ready to perform the first splicing reaction. This occurs by an ATP-dependent conformational change of the pre-catalytic spliceosome. The joining together of exons from one or more primary transcripts of nuclear messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced. The aggregation, arrangement and bonding together of proteins and RNA molecules to form a ribonucleoprotein complex. Structural rearrangements of the spliceosome complex, containing RNA to be spliced, to generate a catalytic conformation. Conformational rearrangement of the spliceosomal complex containing the RNA products from the 1st step of splicing to form the catalytic site for the second step of splicing. The cellular process by which a complex containing RNA and proteins is synthesized, aggregates, and bonds together. Includes the biosynthesis of the constituent RNA and protein molecules, and those macromolecular modifications that are involved in synthesis or assembly of the ribonucleoprotein complex. Rearrangement of the pre-catalytic spliceosome containing U4 (or U4atac) and U1 (or U11) snRNPs to unpair U4 (or U4atac) from U6 (or U6atac) and release it from the spliceosomal complex along with U1 (or U11). Splicing of RNA via a series of two transesterification reactions with a bulged adenosine residue from the intron branch point as the initiating nucleophile. When the initial RNA for the splicing reaction is a single molecule (cis splicing), the excised intron is released in a lariat structure. The aggregation, arrangement and bonding together of a set of macromolecules to form a complex, carried out at the cellular level.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: spliceosomal conformational changes to generate catalytic conformation
Acc: GO:0000393
Aspect: Biological Process
Desc: Structural rearrangements of the spliceosome complex, containing RNA to be spliced, to generate a catalytic conformation.
Synonyms:
  • 3'-splice site cleavage, exon ligation
Proteins in PDR annotated with:
   This term: 2 [Search]
   Term or descendants: 28 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0000393 - spliceosomal conformational changes to generate catalytic conformation (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle