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A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol. The V0 domain of a proton-transporting V-type ATPase found in the vacuolar membrane. The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell. Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. The V0 domain of a proton-transporting V-type ATPase found in the lysosomal membrane. A proton-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of protons across a concentration gradient. The resulting transmembrane electrochemical potential of H+ is used to drive a variety of (i) secondary active transport systems via H+-dependent symporters and antiporters and (ii) channel-mediated transport systems. The complex comprises a membrane sector (V0) that carries out proton transport and a cytoplasmic compartment sector (V1) that catalyzes ATP hydrolysis. V-type ATPases are found in the membranes of organelles such as vacuoles, endosomes, and lysosomes, and in the plasma membrane. A protein complex that forms part of a proton-transporting two-sector ATPase complex and carries out proton transport across a membrane. The proton-transporting domain (F0, V0, or A0) includes integral and peripheral membrane proteins. A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane. Any constituent part of a vacuole, a closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. A proton-transporting two-sector ATPase complex found in the vacuolar membrane, where it acts as a proton pump to mediate acidification of the vacuolar lumen. A protein complex that forms part of a proton-transporting V-type ATPase and mediates proton transport across a membrane. The V0 complex consists of at least four different subunits (a,c,d and e); six or more c subunits form a proton-binding rotor ring.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: vacuolar proton-transporting V-type ATPase, V0 domain
Acc: GO:0000220
Aspect: Cellular Component
Desc: The V0 domain of a proton-transporting V-type ATPase found in the vacuolar membrane.
Synonyms:
  • vacuolar hydrogen ion-transporting ATPase V0 domain
Proteins in PDR annotated with:
   This term: 38 [Search]
   Term or descendants: 38 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0000220 - vacuolar proton-transporting V-type ATPase, V0 domain (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle