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The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins. The chemical reactions and pathways resulting in the breakdown of the nuclear-transcribed mRNA transcript body of an mRNA in which an amino-acid codon has changed to a nonsense codon; occurs when the 3' end is not protected by a 3'-poly(A) tail; degradation proceeds in the 3' to 5' direction. The chemical reactions and pathways resulting in the breakdown of nuclear-transcribed mRNAs in eukaryotic cells. The chemical reactions and pathways resulting in the breakdown of the nuclear-transcribed mRNA transcript body of an mRNA in which an amino-acid codon has changed to a nonsense codon; occurs when the 5' end is not protected by a 5'-cap; degradation proceeds in the 5' to 3' direction. The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
Acc: GO:0000184
Aspect: Biological Process
Desc: The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins.
Synonyms:
  • mRNA breakdown, nonsense-mediated decay
  • nuclear mRNA catabolic process, nonsense-mediated decay
  • mRNA catabolic process, nonsense-mediated
  • mRNA degradation, nonsense-mediated decay
  • nonsense-mediated mRNA decay
  • mRNA catabolism, nonsense-mediated
Proteins in PDR annotated with:
   This term: 114 [Search]
   Term or descendants: 120 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0000184 - nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle