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Protein Overview: MSD1

General Information:
Name(s) found: MSD1 / YPL104W [SGD]
Description(s) found:
Found 27 descriptions.
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  • Mitochondrial aspartyl-tRNA synthetase, required for acylation of aspartyl-tRNA; yeast and bacterial aspartyl-, asparaginyl-, and lysyl-tRNA synthetases contain regions with high sequence similarity, suggesting a common ancestral gene [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 658 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed articleLink to PubMed article][IMPLink to PubMed article][ISSLink to PubMed article]
    Biological Process: translation [IMPLink to PubMed article][ISSLink to PubMed article]
    Molecular Function: aspartate-tRNA ligase activity [IMPLink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLARSRVCLQ TITRRLADFP EANAIKKKFL FRKDTSTIKQ LKGLSSGQKI VLNGWIEQKP  60
   61 KRVGKNLIFG LLRDSNGDII QLVDNKSLLK GFTLEDVVQA VGILSLKRKL SNEDADEYEV 120
  121 QLEDITVLNA SNKKPAQMQD FKLSAIYPPE FRYLQLRNPK YQDFLKKRSS ISKEIRNSFN 180
  181 NFDFTEVETP MLFKATPEGA REFLVPTRTK RSDGKPSFYA LDQSPQQYKQ LLMASGVNKY 240
  241 YQMARCFRDE DLRADRQPEF TQVDMEMAFA NSEDVMKIIE KTVSGVWSKF SKKRGLLTLD 300
  301 SKGTLVPAKK ENGTVSIFRM TYEQAMTSYG IDKPDLRAPD LKIINLGEFN AFSHLNKKFP 360
  361 VFEVIILRSA FSNMEEYKER WSFLTNNSNY NYRVPIVLPI ENDEQANSNW FENFHAIATF 420
  421 ENPHLITKFL KLKKGDIVCG CTREPNHSIF ENPTPLGRLR QLVLQSEHGK NIYHAVNKDV 480
  481 ASWIVDFPLF SPVIIEDKSG KKEKLAYPEY EKDRLCSTHH PFTMVKLKDY EKLEKTPEKC 540
  541 LGRHYDLVVN GVELGGGSTR IHDPRLQDYI FEDILKIDNA YELFGHLLNA FDMGTPPHAG 600
  601 FAIGFDRMCA MICETESIRD VIAFPKSITG ADLVVKSPSV IPESILEPYN IKYSNSKK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Ho Y, et al. (2002) MSD1 PHR1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data MSD1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..139] PSI-BLAST 1742.218487 Aspartyl-tRNA synthetase (AspRS); Prokaryotic AspRS, insert domain
    2 View Details [140..658] PSI-BLAST 1742.218487 Aspartyl-tRNA synthetase (AspRS); Prokaryotic AspRS, insert domain


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle