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Protein Overview: SPE1

General Information:
Name(s) found: SPE1 / YKL184W [SGD]
Description(s) found:
Found 28 descriptions.
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  • Ornithine decarboxylase, catalyzes the first step in polyamine biosynthesis; degraded in a proteasome-dependent manner in the presence of excess polyamines; deletion decreases lifespan, and increases necrotic cell death and ROS generation [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 466 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    Biological Process: pantothenate biosynthetic process [IMPLink to PubMed article]
    putrescine biosynthetic process [IMPLink to PubMed article]
    Molecular Function: ornithine decarboxylase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSTQVGNAL SSSTTTLVDL SNSTVTQKKQ YYKDGETLHN LLLELKNNQD LELLPHEQAH  60
   61 PKIFQALKAR IGRINNETCD PGEENSFFIC DLGEVKRLFN NWVKELPRIK PFYAVKCNPD 120
  121 TKVLSLLAEL GVNFDCASKV EIDRVLSMNI SPDRIVYANP CKVASFIRYA ASKNVMKSTF 180
  181 DNVEELHKIK KFHPESQLLL RIATDDSTAQ CRLSTKYGCE MENVDVLLKA IKELGLNLAG 240
  241 VSFHVGSGAS DFTSLYKAVR DARTVFDKAA NEYGLPPLKI LDVGGGFQFE SFKESTAVLR 300
  301 LALEEFFPVG CGVDIIAEPG RYFVATAFTL ASHVIAKRKL SENEAMIYTN DGVYGNMNCI 360
  361 LFDHQEPHPR TLYHNLEFHY DDFESTTAVL DSINKTRSEY PYKVSIWGPT CDGLDCIAKE 420
  421 YYMKHDVIVG DWFYFPALGA YTSSAATQFN GFEQTADIVY IDSELD

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen SPE1 PRP9 2 Unpublished Fields Lab Data
    View Screen SPE1 YOR364W 2 Unpublished Fields Lab Data
    View Screen SPE1 GLY1 2 Unpublished Fields Lab Data
    View Screen SPE1 YHR112C 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data SPE1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..94]
    [457..466]    		 PSI-BLAST 1026.457575 Eukaryotic ornithine decarboxylase (ODC); Eukaryotic ornithine decarboxylase
    2 View Details [95..326] PSI-BLAST 1026.457575 Eukaryotic ornithine decarboxylase (ODC); Eukaryotic ornithine decarboxylase
    3 View Details [327..456] PSI-BLAST 1026.457575 Eukaryotic ornithine decarboxylase (ODC); Eukaryotic ornithine decarboxylase


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.84

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle