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Protein Overview: DLS1

General Information:
Name(s) found: DLS1 / YJL065C [SGD]
Description(s) found:
Found 29 descriptions.
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  • Subunit of ISW2/yCHRAC chromatin accessibility complex along with Itc1p, Isw2p, and Dpb4p; involved in inheritance of telomeric silencing [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 167 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    chromatin accessibility complex [IPILink to PubMed article]
    Biological Process: chromatin silencing at telomere [IMPLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNNETSGKET ASAPLCSPKL PVEKVQRIAK NDPEYMDTSD DAFVATAFAT EFFVQVLTHE  60
   61 SLHRQQQQQQ QQVPPLPDEL TLSYDDISAA IVHSSDGHLQ FLNDVIPTTK NLRLLVEENR 120
  121 VRYTTSVMPP NEVYSAYVVN DTAPKPNIVE IDLDNDEDDD EDVTDQE

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) DLS1 ELA1 ISW2 ITC1
    View Details Qiu et al. (2008) DLS1 DPB4 ISW2

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data DLS1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..110] PSI-BLAST 20.0 Negative cofactor 2, NC2, alpha chain
    2 View Details [111..167] deduced N/A Confident ab initio structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • DNA binding
    		•  4.49118409263799 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.35201412176948 bayes_pls_golite062009
  • transcription regulator activity
    		•  4.08606081850613 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  4.04353148658823 bayes_pls_golite062009
  • binding
    		•  3.27510691458843 bayes_pls_golite062009
  • transcription factor activity
    		•  2.51581622888695 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.38228606466152 bayes_pls_golite062009
  • transcription repressor activity
    		•  2.3574713307436 bayes_pls_golite062009
  • transcription corepressor activity
    		•  1.30859203490073 bayes_pls_golite062009
  • transcription activator activity
    		•  1.25487495162413 bayes_pls_golite062009
  • transcription factor binding
    		•  1.15204005455906 bayes_pls_golite062009
  • transcription coactivator activity
    		•  1.1297723528047 bayes_pls_golite062009
  • protein binding
    		•  1.07873333188144 bayes_pls_golite062009
  • transcription cofactor activity
    		•  1.01502031330902 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.0852726470007639 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle